{"text_format":"1","workbook":"xlsx","n_sheets":17,"sheets":["Factor Data","Node Data","Arc Data","NodeCopy Data","Dependency Data","Trigger Data","_Lookup","_Cohort","Therapy","Kidney","Cancer","MortDial","MortMel","MortBkd","Sheet0","Sheet1","Sheet2"],"not_rendered":{"charts":0,"images":2,"macros":1,"external_links":1,"defined_names":51,"comments":1,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Factor Data","index":0,"n_rows":56,"n_cols":4,"rows_kept":56,"cut":false,"hidden":true,"merged":[]}
["Entry Count",6]
["Next Available ID",7]
[]
["ID",1]
["IsActive",true]
["NodeID",1,2,3]
["ArcID",1,2]
["fNodeCopyID"]
["RootNodeID",1]
["FactorName","Therapy"]
["IsHidden",false]
[]
["ID",2]
["IsActive",true]
["NodeID",4,5]
["ArcID",11]
["fNodeCopyID"]
["RootNodeID",4]
["FactorName","Kidney"]
["IsHidden",false]
[]
["ID",3]
["IsActive",true]
["NodeID",6,7]
["ArcID",4]
["fNodeCopyID"]
["RootNodeID",6]
["FactorName","Cancer"]
["IsHidden",false]
[]
["ID",4]
["IsActive",true]
["NodeID",8]
["ArcID",5]
["fNodeCopyID"]
["RootNodeID",8]
["FactorName","MortDial"]
["IsHidden",false]
[]
["ID",5]
["IsActive",true]
["NodeID",9]
["ArcID",6]
["fNodeCopyID"]
["RootNodeID",9]
["FactorName","MortMel"]
["IsHidden",false]
[]
["ID",6]
["IsActive",true]
["NodeID",10]
["ArcID",7]
["fNodeCopyID"]
["RootNodeID",10]
["FactorName","MortBkd"]
["IsHidden",false]

{"sheet":"Node Data","index":1,"n_rows":122,"n_cols":3,"rows_kept":122,"cut":false,"hidden":true,"merged":[]}
["Entry Count",10]
["Next Available ID",11]
[]
["ID",1]
["nParentFactorID",1]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",2,1]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","0"]
["Rounded",false]
["nTriggerID"]
[]
["ID",2]
["nParentFactorID",1]
["NodeCopyID"]
["PredecessorArcID",1]
["SuccessorArcID"]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","No Immunosuppress"]
["Rounded",true]
["nTriggerID"]
[]
["ID",3]
["nParentFactorID",1]
["NodeCopyID"]
["PredecessorArcID",2]
["SuccessorArcID"]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Immunosuppress"]
["Rounded",true]
["nTriggerID"]
[]
["ID",4]
["nParentFactorID",2]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",11]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Well"]
["Rounded",true]
["nTriggerID"]
[]
["ID",5]
["nParentFactorID",2]
["NodeCopyID"]
["PredecessorArcID",11]
["SuccessorArcID"]
["QualityFactor","qDial"]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Dialysis"]
["Rounded",true]
["nTriggerID"]
[]
["ID",6]
["nParentFactorID",3]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",4]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Remission"]
["Rounded",true]
["nTriggerID"]
[]
["ID",7]
["nParentFactorID",3]
["NodeCopyID"]
["PredecessorArcID",4]
["SuccessorArcID"]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Melanoma"]
["Rounded",true]
["nTriggerID"]
[]
["ID",8]
["nParentFactorID",4]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",5]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Alive"]
["Rounded",true]
["nTriggerID"]
[]
["ID",9]
["nParentFactorID",5]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",6]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Alive"]
["Rounded",true]
["nTriggerID"]
[]
["ID",10]
["nParentFactorID",6]
["NodeCopyID"]
["PredecessorArcID"]
["SuccessorArcID",7]
["QualityFactor",1]
["CostFactor",0]
["IsKeyNode",false]
["NodeName","Alive"]
["Rounded",true]
["nTriggerID"]

{"sheet":"Arc Data","index":2,"n_rows":86,"n_cols":2,"rows_kept":86,"cut":false,"hidden":true,"merged":[]}
["Entry Count",7]
["Next Available ID",12]
[]
["ID",1]
["aParentFactorID",1]
["Stochastic",false]
["Orientation",3.1415927410125732]
["PredecessorNodeID",1]
["SuccessorNodeID",2]
["SuccessorNodeCopyID",0]
["TriggerID",1]
["RateProb","Stop"]
["QualityToll",0]
["CostToll",0]
[]
["ID",2]
["aParentFactorID",1]
["Stochastic",false]
["Orientation",3.1415927410125732]
["PredecessorNodeID",1]
["SuccessorNodeID",3]
["SuccessorNodeCopyID",0]
["TriggerID"]
["RateProb","1-Stop"]
["QualityToll",0]
["CostToll",0]
[]
["ID",4]
["aParentFactorID",3]
["Stochastic",true]
["Orientation",3.1415927410125732]
["PredecessorNodeID",6]
["SuccessorNodeID",7]
["SuccessorNodeCopyID",0]
["TriggerID"]
["RateProb","ID 4"]
["QualityToll",0]
["CostToll",0]
[]
["ID",5]
["aParentFactorID",4]
["Stochastic",true]
["Orientation",-1.5707963705062866]
["PredecessorNodeID",8]
["SuccessorNodeID",0]
["SuccessorNodeCopyID",0]
["TriggerID"]
["RateProb","ID 2"]
["QualityToll",0]
["CostToll",0]
[]
["ID",6]
["aParentFactorID",5]
["Stochastic",true]
["Orientation",-1.5707963705062866]
["PredecessorNodeID",9]
["SuccessorNodeID",0]
["SuccessorNodeCopyID",0]
["TriggerID"]
["RateProb","ID 3"]
["QualityToll",0]
["CostToll",0]
[]
["ID",7]
["aParentFactorID",6]
["Stochastic",true]
["Orientation",-1.5707963705062866]
["PredecessorNodeID",10]
["SuccessorNodeID",0]
["SuccessorNodeCopyID",0]
["TriggerID"]
["RateProb","rMortUS(_t+InitAge,Gender)"]
["QualityToll",0]
["CostToll",0]
[]
["ID",11]
["aParentFactorID",2]
["Stochastic",true]
["Orientation",3.1415927410125732]
["PredecessorNodeID",4]
["SuccessorNodeID",5]
["SuccessorNodeCopyID",0]
["TriggerID",4]
["RateProb","rReject"]
["QualityToll",0]
["CostToll",0]

{"sheet":"NodeCopy Data","index":3,"n_rows":2,"n_cols":2,"rows_kept":2,"cut":false,"hidden":true,"merged":[]}
["Entry Count",0]
["Next Available ID",1]

{"sheet":"Dependency Data","index":4,"n_rows":17,"n_cols":3,"rows_kept":17,"cut":false,"hidden":true,"merged":[]}
["Entry Count",3]
["Next Available ID",5]
[]
["ID",2]
["IfFactorID",2]
["StateID",5,"(other)"]
["ThenD","mxBase+mxDial","mxBase"]
[]
["ID",3]
["IfFactorID",3]
["StateID",7,"(other)"]
["ThenD","mxMel",0]
[]
["ID",4]
["IfFactorID",1]
["StateID",3,2]
["ThenD","rRecur Immuno","rRecur No_Immuno"]

{"sheet":"Trigger Data","index":5,"n_rows":12,"n_cols":2,"rows_kept":12,"cut":false,"hidden":true,"merged":[]}
["Entry Count",2]
["Next Available ID",5]
[]
["ID",1]
["FactorTriggeredID",2]
["OriginNodeID",4]
["DestinationNodeID",5]
[]
["ID",4]
["FactorTriggeredID",1]
["OriginNodeID","(any node)"]
["DestinationNodeID",2]

{"sheet":"_Lookup","index":6,"n_rows":10,"n_cols":2,"rows_kept":10,"cut":false,"hidden":true,"merged":[]}
["Next Available Dive Index",6]
["Begin Table",5]
["End Table",11]
[]
["Lexicographic Node Index","Dive Index"]
[1,1]
[7,3]
[8,4]
[9,2]
[10,5]

{"sheet":"_Cohort","index":7,"n_rows":54,"n_cols":11,"rows_kept":54,"cut":false,"hidden":false,"merged":[]}
[]
["Cycle Time =",0.1]
["Start Time =",0]
["Time Horizon =",20]
["Discount Rate =",{"$f":"_DiscountRate","v":0}]
[null,null,null,"Therapy:","0","No Immunosuppress","No Immunosuppress","Immunosuppress","Immunosuppress","Terminal Node"]
[null,null,null,"Kidney:","Well","Dialysis","Dialysis","Well","Well"]
[null,null,null,"Cancer:","Remission","Remission","Melanoma","Remission","Melanoma"]
[null,null,null,"MortDial:","Alive","Alive","Alive","Alive","Alive"]
[null,null,null,"MortMel:","Alive","Alive","Alive","Alive","Alive"]
[null,null,null,"MortBkd:","Alive","Alive","Alive","Alive","Alive"]
[null,null,null,"Chance/Decision?",1,0,0,0,0]
[]
[null,null,null,"Initial Cohort =",1]
[]
[null,null,null,"Time","Counts"]
[null,null,null,{"$f":"IF(_R,_tI,IF(_t>_tF,_tNw,D26))","v":1.9000000000000006},{"$f":"IF(_R,E14,IF(_tNw>=_tF,E17,E26))","v":0},3.666960007414706E-2,1.4470903076954934E-2,0.42555887113464119,0.37750822559729924,0.1457924001169576,{"$f":"(SUMPRODUCT(E12:K12,E17:K17) > 0)","v":false}]
[null,null,"Transition Counts:"," 0 / Well / Remission / Alive / Alive / Alive "," "]
[null,null,null," No Immunosuppress / Dialysis / Remission / Alive / Alive / Alive ",{"$f":"Stop","v":0},null,null,{"$f":"[1]!xPr(rReject*_dT)","v":3.3372684353971671E-3}]
[null,null,null," No Immunosuppress / Dialysis / Melanoma / Alive / Alive / Alive "," ",{"$f":"[1]!xPr(rRecur No_Immuno*_dT)","v":5.8066226622963679E-3},null,null,{"$f":"[1]!xPr(rReject*_dT)","v":3.3372684353971671E-3}]
[null,null,null," Immunosuppress / Well / Remission / Alive / Alive / Alive ",{"$f":"(1-Stop)","v":1}]
[null,null,null," Immunosuppress / Well / Melanoma / Alive / Alive / Alive "," ",null,null,{"$f":"[1]!xPr(rRecur Immuno*_dT)","v":3.497025848152524E-2}]
[null,null,null,"Terminal Node"," ",{"$f":"[1]!xPr(((mxBase+mxDial)+[1]!rMortUS(_t+InitAge,Gender))*_dT)","v":1.1223918387861964E-2},{"$f":"[1]!xPr(((mxBase+mxDial)+mxMel+[1]!rMortUS(_t+InitAge,Gender))*_dT)","v":2.0964506130376259E-2},{"$f":"[1]!xPr((mxBase+[1]!rMortUS(_t+InitAge,Gender))*_dT)","v":5.6712393404950712E-3},{"$f":"[1]!xPr((mxBase+mxMel+[1]!rMortUS(_t+InitAge,Gender))*_dT)","v":1.5466527392283269E-2}]
[null,null,null,"Entering Counts",{"$f":"SUMPRODUCT(_tR,E18:J18)","v":0},{"$f":"SUMPRODUCT(_tR,E19:J19)","v":1.4202041880408886E-3},{"$f":"SUMPRODUCT(_tR,E20:J20)","v":1.4727728161965463E-3},{"$f":"SUMPRODUCT(_tR,E21:J21)","v":0},{"$f":"SUMPRODUCT(_tR,E22:J22)","v":1.4881903722684492E-2},{"$f":"SUMPRODUCT(_tR,E23:J23)","v":8.9671394585049968E-3}]
[null,null,null,"Departing Counts",{"$f":" IF(_CD=1,E17,E17*SUM(E18:E23))","v":0},6.2450312935565053E-4,3.0337533626890236E-4,1.8715554122400831E-2,7.0985875974015405E-3,0]
[null,null,null,{"$f":"IF(_CP,D17,D17+_dT)","v":2.0000000000000004},{"$f":"E17+E24-E25","v":0},3.74653011328323E-2,1.5640300556882578E-2,0.40684331701224036,0.38529154172258218,0.1547595395754626]
[]
[null,null,null,"Quality Coefficients (at t):",null,{"$f":"qDial","v":0.7},{"$f":"qDial","v":0.7},{"$f":"1","v":1},{"$f":"1","v":1}]
[null,null,null,"(at t+dt):",null,{"$f":"qDial*EXP(-_dR*_dT)","v":0.7},{"$f":"qDial*EXP(-_dR*_dT)","v":0.7},{"$f":"EXP(-_dR*_dT)","v":1},{"$f":"EXP(-_dR*_dT)","v":1}]
[]
[null,null,"Transition QALY Tolls:"," Immunosuppress / Well / Remission / Alive / Alive / Alive ",{"$f":"0","v":0}]
[null,null,null," No Immunosuppress / Dialysis / Remission / Alive / Alive / Alive ",{"$f":"0","v":0},null,null,{"$f":"0","v":0}]
[null,null,null," No Immunosuppress / Dialysis / Melanoma / Alive / Alive / Alive "," ",{"$f":"0","v":0},null,null,{"$f":"0","v":0}]
[null,null,null," Immunosuppress / Well / Melanoma / Alive / Alive / Alive "," ",null,null,{"$f":"0","v":0}]
[null,null,null,"Terminal Node"," ",{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0}]
[null,null,null,"Incremental QALY Tolls:",{"$f":"IF(_t>_tF,0,_tR*SUM(E31:E35))","v":0},{"$f":"IF(_t>_tF,0,_tR*SUM(F31:F35))","v":0},{"$f":"IF(_t>_tF,0,_tR*SUM(G31:G35))","v":0},{"$f":"IF(_t>_tF,0,_tR*SUM(H31:H35))","v":0},{"$f":"IF(_t>_tF,0,_tR*SUM(I31:I35))","v":0}]
[null,null,null,"Incremental QALYs:",{"$f":"IF(_t>_tF,0,IF(_CP,0,_dT/2*(E28*E17+E29*E26)))","v":0},{"$f":"IF(_t>_tF,0,IF(_CP,0,_dT/2*(F28*F17+F29*F26)))","v":2.5947215422442776E-3},{"$f":"IF(_t>_tF,0,IF(_CP,0,_dT/2*(G28*G17+G29*G26)))","v":1.0538921271843128E-3},{"$f":"IF(_t>_tF,0,IF(_CP,0,_dT/2*(H28*H17+H29*H26)))","v":4.1620109407344077E-2},{"$f":"IF(_t>_tF,0,IF(_CP,0,_dT/2*(I28*I17+I29*I26)))","v":3.8139988365994075E-2}]
[null,null,null,"Incremental Total:",{"$f":"E37-E36","v":0},{"$f":"F37-F36","v":2.5947215422442776E-3},{"$f":"G37-G36","v":1.0538921271843128E-3},{"$f":"H37-H36","v":4.1620109407344077E-2},{"$f":"I37-I36","v":3.8139988365994075E-2}]
[null,null,null,"Cum Discounted QALYs:",{"$f":"IF(_R,E38,IF(_t>=_tF,E39,E39+E38*EXP(-_dR*_t)))","v":0},{"$f":"IF(_R,F38,IF(_t>=_tF,F39,F39+F38*EXP(-_dR*_t)))","v":3.2377608754148558E-2},{"$f":"IF(_R,G38,IF(_t>=_tF,G39,G39+G38*EXP(-_dR*_t)))","v":8.1877744224366413E-3},{"$f":"IF(_R,H38,IF(_t>=_tF,H39,H39+H38*EXP(-_dR*_t)))","v":1.31939148543881},{"$f":"IF(_R,I38,IF(_t>=_tF,I39,I39+I38*EXP(-_dR*_t)))","v":0.479260419833759}]
[null,null,null,"Overall Cum QALYs =",{"$f":"SUM(E39:I39)","v":1.839217288449154}]
[]
[null,null,null,"Cost Coefficients (at t):",null,{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0}]
[null,null,null,"(at t+dt):",null,{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0},{"$f":"0","v":0}]
[]
[null,null,"Transition Cost Tolls:"," Immunosuppress / Well / Remission / Alive / Alive / Alive "]
[null,null,null," No Immunosuppress / Dialysis / Remission / Alive / Alive / Alive "]
[null,null,null," No Immunosuppress / Dialysis / Melanoma / Alive / Alive / Alive "]
[null,null,null," Immunosuppress / Well / Melanoma / Alive / Alive / Alive "]
[null,null,null,"Terminal Node"]
[null,null,null,"Incremental Cost Tolls:"]
[null,null,null,"Incremental Costs:"]
[null,null,null,"Incremental Total:"]
[null,null,null,"Cum Discounted Costs:"]
[null,null,null,"Overall Cum Costs ="]

{"sheet":"Therapy","index":8,"n_rows":3,"n_cols":6,"rows_kept":3,"cut":false,"hidden":false,"merged":[]}
[]
[]
[null,null,null,"Stop =",0,"1 if stop immunosuppression initially; 0 if continue"]

{"sheet":"Kidney","index":9,"n_rows":3,"n_cols":19,"rows_kept":3,"cut":false,"hidden":false,"merged":[]}
[]
[null,null,null,null,"rReject =",{"$f":"1-EXP(-Q2)","v":3.3428495362493371E-2},{"$f":"\"/yr\"","v":"/yr"},"Rate of kidney rejection under immunosupression",null,null,null,null,null,null,null,"pReject =",3.4000000000000002E-2,{"$f":"\"/yr\"","v":"/yr"},"From Beck and Sonnenberg"]
[null,null,null,null,"qDial =",0.7,null,"Quality of life under dialysis"]

{"sheet":"Cancer","index":10,"n_rows":3,"n_cols":17,"rows_kept":3,"cut":false,"hidden":false,"merged":[]}
[null,null,null,null,"Immuno","No Immuno",null,null,null,null,null,null,"From Beck and Sonnenberg:"]
[null,null,null,"rRecur: ",{"$f":"1-EXP(-O2)","v":0.35596357891685859},{"$f":"1-EXP(-O3)","v":5.823546641575128E-2},null,null,null,null,null,null,null,"pRecur =",0.44,{"$f":"\"/yr\"","v":"/yr"},"under immunosupression"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,0.06,{"$f":"\"/yr\"","v":"/yr"},"without immunosuppression"]

{"sheet":"MortDial","index":11,"n_rows":3,"n_cols":7,"rows_kept":3,"cut":false,"hidden":false,"merged":[]}
[]
[null,null,null,"mxBase =",5.3999999999999999E-2,{"$f":"\"/yr\"","v":"/yr"},"Excess mortality due to transplant and prior melanoma"]
[null,null,null,"mxDial =",5.6000000000000001E-2,{"$f":"\"/yr\"","v":"/yr"},"Excess mortality due to dialysis"]

{"sheet":"MortMel","index":12,"n_rows":2,"n_cols":7,"rows_kept":2,"cut":false,"hidden":false,"merged":[]}
[]
[null,null,null,"mxMel =",9.9000000000000005E-2,{"$f":"\"/yr\"","v":"/yr"},"Excess mortality due to melanoma"]

{"sheet":"MortBkd","index":13,"n_rows":3,"n_cols":5,"rows_kept":3,"cut":false,"hidden":false,"merged":[]}
[]
[null,null,null,"InitAge =",42]
[null,null,null,"Gender =","Male"]

{"sheet":"Sheet0","index":14,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}

{"sheet":"Sheet1","index":15,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}

{"sheet":"Sheet2","index":16,"n_rows":0,"n_cols":0,"rows_kept":0,"cut":false,"hidden":false,"merged":[]}