Ajit C. Tamhane
Senior Associate Dean (Graduate Studies and Planning), McCormick School of Engineering and Applied Science
Professor, Department of Industrial Engineering and Management Sciences
Professor (by courtesy), Department of Statistics

Contact Information
Department of Industrial Engineering and Management Sciences, Northwestern University
2145 Sheridan Road
Room C250, L254
Evanston, IL 60208-3119
Phone: 847-491-3577, 847-467-4909
Fax: 847-491-8005
E-mail: atamhane@northwestern.edu

Page Map

  1. Education
  2. Professional Experience
  3. Honors and Awards
  4. Research Interests
  5. Books and Monographs
  6. Research Papers
  7. Sponsored Research
  8. Graduate Student Supervision
  9. Seminars and Talks
  10. Short Courses
  11. Consulting
  12. Professional Activities

Education

Professional Experience

Honors and Awards

Research Interests

Books and Monographs

Multiple Testing Problems in Pharmaceutical Statistics, co-edited with A. Dmitrienko and F. Bretz, Taylor & Francis (2009)

 


 

 

 

 

 

 

 

Statistical Analysis of Designed Experiments: Theory and Applications, John Wiley (2009)

 


 

 

 

Statistics and Data Analysis: From Elementary to Intermediate, co-authored with D. Dunlop, Prentice Hall (2000)

 

 

 

 

 

 

 

Download the Minitab data files

Multiple Comparison Procedures, co-authored with Y. Hochberg, John Wiley, (1987)

 

 

 

 

 

 

 

Design of Experiments: Ranking and Selection (Essays in Honor of Robert E. Bechhofer), co-edited with T. J. Santner, Marcel-Dekker, (1984)

Research Papers

By Topic

 

    Multiple Comparisons (Including Multiple Endpoints, Dose Finding and Design of Experiments)

  1. "Multiple comparisons in model I one-way ANOVA with unequal variances," Communications in Statistics, Ser. A (1977), 6, 15-32
  2. "A comparison of procedures for multiple comparisons of means with unequal variances," Journal of the American Statistical Association (1979), 74, 471-480
  3. "Incomplete block designs for comparing treatments with a control: General theory," (with R. E. Bechhofer), Technometrics (1981), 23, 45-57
  4. "Design of experiments for comparing treatments with a control: Tables of optimal allocations of observations," (with R. E. Bechhofer), Technometrics (1983), 25, 87-95
  5. "Balanced treatment incomplete block (BTIB) designs for comparing treatments with a control: Minimal complete sets of generator designs for k = 3, p = 3(1)10," (with W. I. Notz), Communications in Statistics, Ser. A, (1983), 12, 1391-1412
  6. "Incomplete block designs for comparing treatments with a control (II): Optimal designs for p = 2(1)6, k = 2 and p = 3, k = 3," (with R. E. Bechhofer), Sankhyā, Ser. B (1983), 45, 193-224
  7. "Multiple comparisons in a mixed model," (with Y. Hochberg), The American Statistician (1983), 37, 305-307
  8. "Tables of admissible and optimal BTIB designs for comparing treatments with a control," (with R. E. Bechhofer), Selected Tables in Mathematical Statistics (1985), 8, 41-139
  9. "An optimal procedure for partitioning a set of normal populations with respect to a control," Sankhyā, Ser. A (1987), 49, 335-346
  10. "Discussion of the paper 'Optimal designs for comparing treatments with controls' by A. S. Hedayat, M. Jacroux and D. Majumdar," (with R. E. Bechhofer), Statistical Science (1988), 3, 477-480
  11. "Two-stage procedures for comparing treatments with a control: Elimination at the first stage and estimation at the second stage," (with R. E. Bechhofer and C. W. Dunnett), Biometrical Journal (1989), 31, 545-561
  12. "Sample size determination for step-down multiple test procedures: Orthogonal contrasts and comparisons with a control," (with A. J. Hayter), Journal of Statistical Planning and Inference (1990), 27, 271-290
  13. "Step-down multiple tests for comparing treatments with a control in unbalanced one-way layouts," (with C. W. Dunnett), Statistics in Medicine (1991), 10, 939-947
  14. "A step-up multiple test procedure," (with C. W. Dunnett), Journal of the American Statistical Association, (1992), 87, 162-170
  15. "A Bayesian approach to comparing treatments with a control," (with G. V. S. Gopal) (1992), Multiple Comparisons, Selection and Applications to Biometry, A Festschrift in Honor of Charles W. Dunnett, (Ed. F. Hoppe), Marcel-Dekker, 267-292
  16. "Comparisons between a new drug and active and placebo controls in an efficacy clinical trial," (with C. W. Dunnett), Statistics in Medicine, (1992), 11, 1057-1063
  17. "Power comparisons of some step-up multiple test procedures," (with C. W. Dunnett), Statistics and Probability Letters, (1993), 16, 55-58
  18. "Step-up multiple testing of parameters with unequally correlated estimates," (with C. W. Dunnett), Biometrics, (1995), 51, 217-227
  19. "Row column designs for comparing treatments with a control," (with D. Majumdar), Journal of Statistical Planning and Inference, (1996), 49, 387-400
  20. "Multiple test procedures for dose finding," (with Y. Hochberg and C. W. Dunnett), Biometrics, (1996), 52, 21-37
  21. "Multiple comparisons," Chapter 18 in Handbook of Statistics, vol. 13, (Eds. S. Ghosh and C. R. Rao), (1996), Elsevier Science B. V., 587-630
  22. "Multiple testing to establish superiority/equivalence of a new treatment with k standard treatments," (with C. W. Dunnett), Statistics in Medicine, (1997), 16, 2489-2506
  23. "A generalized step-up-down multiple test procedure," (with W. Liu and C. W. Dunnett), Canadian Journal of Statistics, (1998), 26, 353-363
  24. "Some new multiple test procedures with biometric applications," (with C. W. Dunnett), Journal of Biopharmaceutical Statistics, (1998), 8, 353-366
  25. "Stepwise multiple test procedures with biometric applications," (with C. W. Dunnett), Journal of Statistical Planning and Inference, (1999), 82, 55-68
  26. "Multiple test procedures for identifying the maximum safe dose," (with C. W. Dunnett, J. Green and J. Wetherington), Journal of the American Statistical Association, (2001), 96, 835-843
  27. "Combining global and marginal tests to compare two treatments on multiple endpoints," (with B. R. Logan), Biometrical Journal, (2001), 43, 591-604
  28. "Nonparametric multiple comparisons in repeated measures designs for data with ties (with U. Munzel), Biometrical Journal, (2002), 44, 762-779
  29. "Multiple test procedures for identifying the minimum effective and maximum safe doses of a drug," (with B. R. Logan), Journal of the American Statistical Association, (2002), 97, 293-301
  30. "Accurate critical constants for the one-sided approximate likelihood ratio test of a normal mean vector when the covariance matrix is estimated," (with B. R. Logan), Biometrics, (2002), 58, 176-182
  31. "On O'Brien's OLS and GLS tests for multiple endpoints," (with B. R. Logan), in "Recent Developments in Multiple Comparison Procedures," IMS Lecture Notes and Monograph Series (Eds.: Y. Benjamini, F. Bretz and S. Sarkar), (2004), 76-88
  32. "A superiority-equivalence approach to one-sided tests on multiple endpoints in clinical trials," (with B. R. Logan), Biometrika, (2004), 91, 715-727
  33. "Comparing variances of several measurement methods using a randomized block design with repeat measurements: A case study," (with A. J. Hayter), in "Advances in Ranking and Selection, Multiple Comparisons and Reliability (Essays in Honor of S. Panchapkesan), Birkh„user/Springer-Verlag, (2005), 165-178
  34. "Finding the maximum safe dose for heteroscedastic data," (with B. R. Logan), Journal of Biopharmaceutical Statistics, (2004), 14, 843-856
  35. "Discussion of 'False Discovery Rate Adjusted Multiple Confidence Intervals for Selected Parameters' by Y. Benjamini and D. Yekutieli," Journal of the American Statistical Association, (2005), 100, 84-85
  36. "Multiple comparison procedures for dose response studies," (with B. R. Logan), Design and Analysis of Dose Response Clinical Trials, (Ed. N. Ting), Springer (2006), 172-183
  37. "Power and sample size determination for a multiple test procedure for finding the maximum safe dose," (with K. S. Shi and K. Strassburger), Journal of Statistical Planning and Inference, (2006), 136, 2163-2181
  38. "Stepwise gatekeeping procedures in clinical trial applications," (with A. Dmitrienko, X. Wang and X. Chen), Biometrical Journal, (2007), 48, 984-991
  39. "Tree-structured gatekeeping procedures for multiple objectives in clinical trials," (with A. Dmitrienko, B. Wiens and X. Wang), Statistics in Medicine, 26, 2465-2478
  40. "Gatekeeping procedures with clinical trial applications," (with A. Dmitrienko), Journal of Pharmaceutical Statistics, (2007), 6, 171-180
  41. "On weighted Hochberg procedures," (with L. Liu), Biometrika, (2008), 95, 279-294
  42. "General multistage gatekeeping procedures," (with A. Dmitrienko), Biometrical Journal, 50, 667-677
  43. "Superiority inferences on individual endpoints following equivalence testing in clinical trials," (with B. Logan), Biometrical Journal, (2008), 50, 693-703
  44. "A note on tree gatekeeping procedures in clinical trials," (with A. Dmitrienko, L. Liu and B. Wiens), Statistics in Medicine, (2008), 27, 3446-3451
  45. "Parametric mixture models for estimating the proportion of true null hypotheses and adaptive control of FDR," (with J. Shi), (2009), IMS Lecture-Monograph Series, 57, Optimality: The Third Lehmann Symposium (ed. Javier Rojo), 304-325
  46. "Testing a primary and a secondary endpoint in a group sequential design," (with C. Mehta and L. Liu), Biometrics, (2010), to appear.
  47. "Mixtures of multiple testing procedures for gatekeeping applicationis in clinical trials," (with A. Dmitrienko), Statistics in Medicine, (2011), 30, 1473-1488.
  48. "Multistage and mixture gatekeeping procedures in clinical trials," (with A. Dmitrienko and G. Kordzkhia), Journal of Pharmaceutical Statistics, (2011), 21, 726-747.
  49. "A mixture gatekeeping procedure based on the Hommel test for clinical trial applications," (with T. Brenchenmacher, J. Xu and A. Dmitrienko), Journal of Pharmaceutical Statistics, (2011), 21, 748-767.
  50. "Adaptive extensions of a two-stage group sequential procedure for testing a primary and a secondary endpoint (I): Unknown correlation between the endpoints," (with Y. Wu and C.R. Mehta), Statistics in Medicine, (2012), 31, 2027-2040.
  51. "Adaptive extensions of a two-stage group sequential procedure for testing a primary and a secondary endpoint (II): Sample size re-estimation," (with Y. Wu and C.R. Mehta), Statistics in Medicine, (2012), 31, 2041-2054.
  52. "General theory of mixture procedures for gatekeeping," (with A. Dmitrienko), Biometrical Journal, (2013), 55, 402-419.
  53. "A class of improved hybrid Hochberg-Hommel type step-up multiple test procedures," (with J. Gou, D. Xi and D. Rom), Biometrika, 101, 899-911.
  54. "A general multistage procedure for k-out-of-n gatekeeping," (with D. Xi), Statistics in Medicine, (2014), 33, 1321-1335.
  55. "On generalized Simes critical constants," (with J. Gou), (2014), Biometrical Journal, 56, 1035-1054.
  56. "Allocating recycled signi cance levels in group sequential procedures for multiple endpoints," (with D. Xi), Biometrical Journal, (2015),57, 90-107.
  57. "Hochberg multiple test procedure under negative dependence," (with J. Gou), (2015), submitted for publication.
  58. "Estimation of a parametric function associated with the lognormal distribution," (with J. Gou), (2015), submitted for publication.
    59.

    Ranking and Selection Procedures

  59. "An iterated integral representation for a multivariate normal integral having block covariance structure," (with R. E. Bechhofer), Biometrika (1974), 61, 615-619
  60. "A three-stage elimination type procedure for selecting the largest normal mean (common unknown variance)," Sankhyā, Ser. B (1976), 38, 339-349
  61. "Ranking and selection problems for normal populations with common known coefficient of variation," Sankhyā, Ser. B (1977), 39, 344-361
  62. "A two-stage minimax procedure with screening for selecting the largest normal mean," (with R. E. Bechhofer), Communications in Statistics, Ser. A (1977), 6, 1003-1033
  63. "A two-stage minimax procedure with screening for selecting the largest normal mean (II): An improved PCS lower bound and associated tables," (with R. E. Bechhofer), Communications in Statistics, Ser. A (1979), 8, 337-358
  64. "Selecting the better Bernoulli treatment using a matched samples design," Journal of the Royal Statistical Society, Ser. B (1980), 42, 26-30
  65. "On a class of multistage selection procedures with screening for the normal means problem," Sankhyā, Ser. B (1980), 42, 197-216
  66. "Designing experiments for selecting a normal population with a large mean and a small variance," (with T. J. Santner), Design of Experiments: Ranking and Selection (Eds. T. J. Santner and A. C. Tamhane), Marcel-Dekker, (1984), 179-198
  67. "Some sequential procedures for selecting the better Bernoulli treatment by using a matched samples design,"Journal of the American Statistical Association (1985), 80, 455-460
  68. "A survey of literature on quantal response curves with a view toward application to the problem of selecting the curve with the smallest q-quantile (ED100q)," Communications in Statistics, Ser. A (1986), 15, 2679-2718
  69. "Designing experiments for selecting the largest normal mean when the variances are known and unequal: Optimal sample size allocation," (with R. E. Bechhofer and A. J. Hayter), Journal of Statistical Planning and Inference (1991), 28, 271-289
  70. "Selecting the normal population with the smallest coefficient of variation," (with A. J. Hayter), American Journal of Mathematical and Management Sciences, (2009), 29, 31-50.
    71.

    Chemical Engineering Applications, Quality Control and Data Mining

  71. "Detection of gross errors in process data," (with R. S. H. Mah)," AIChE Journal (1982), 28, 828-830
  72. "Performance studies of the measurement test for detection of gross errors in process data," (with C. Iordache and R. S. H. Mah), AIChE Journal (1985), 27, 1187-1201
  73. "Data reconciliation and gross error detection in chemical process networks," (with R. S. H. Mah), Technometrics (1985), 27, 409-422
  74. "A composite statistical test for detecting changes of steady states," (with S. Narasimhan, R. S. H. Mah, J. W. Woodward and J. C. Hale), AIChE Journal (1986), 32, 1409-1418
  75. "A Bayesian approach to gross error detection in chemical process data (I): Model development," (with C. Iordache and R. S. H. Mah), Chemometrics and Intelligent Laboratory Systems (1988), 4, 33-45
  76. "A Bayesian approach to gross error detection in chemical process data (II): Simulation results," (with C. Iordache and R. S. H. Mah), Chemometrics and Intelligent Laboratory Systems (1988), 4, 131-146
  77. "Gross error detection in serially correlated process data," (with C. J. Kao and R. S. H. Mah), Industrial and Engineering Chemistry Research (1990), 29, 1004-1012
  78. "Gross error detection in serially correlated process data (II): Dynamic systems," (with C. J. Kao and R. S. H. Mah), Industrial and Engineering Chemsitry Research, (1992), 31, 254-262
  79. "A general prewhitening procedure for process and measurement noises," (with C. J. Kao and R. S. H. Mah), Chemical Engineering Communications, (1992), 118, 49-57
  80. "Process trending with piecewise linear smoothing," (with R. S. H. Mah, A. Patel and S. H. Tung), Computers and Chemical Engineering, (1995), 19, 127-136
  81. "Nonlinear partial least squares," (with E. Malthouse and R. S. H. Mah), Computers and Chemical Engineering, (1997), 21, 875-890
  82. "Control charts for autocorrelated process data," (with E. Malthouse), (1997), Chapter 24 in Advances in Statistical Decision Theory and Applications (eds. S. Panchapakesan and N. Balakrishnan), Amsterdam: North Holland, 371-385
  83. "The beta distribution as a latent response model for ordinal data (I): Estimation of location and dispersion parameters," (with B. A. Ankenman and Y. Yang), Journal of Statistical Computing and Simulation, (2002), 72, 473-494
  84. "A comparative study of the K-means algorithm and the normal mixture model for clustering: Univariate case," (with D. Qiu), Journal of Statistical Planning and Inference, (2007), 137, 3722-3740
  85. "A parametric mixture model for clustering multivariate correlated Bernoulli data," (with B. A. Ankenman and D. Qiu), (2008), Statistical Analysis and Data Mining, (2010), 3, 3-17.
    86.

    Biomedical Applications

  86. "Conflicting birthweight and infant mortality trends in a high-risk urban neighborhood," (with J. Reis and S. R. Pliska), Center for Health Services and Policy Research Tech. Report (1985), Northwestern University
  87. "Comparison of the hampster sperm motility assay to the mouse one-cell and two-cell embryo bioassays as quality control tests for in vitro fertilization," (with M. J. Gorrill, J. S. Rinehart and M. Gerrity), Fertility and Sterility (1991), 55, 345-354
  88. "Clinical assessment of venous thromboembolic risk in surgical patients," (with J. A. Caprini, J. I. Arcelus, J. H. Hasty and F. Fabrega), Seminars in Thrombosis and Hemostasis (1991), 17(3), 304-312
  89. "A model-based approach for estimating the AIDS-free time distribution using longitudinal data," (with D. D. Dunlop, J. Chmiel and J. P. Phair), Journal of Biopharmaceutical Statistics, (1994), 4, 129-146
  90. "Risk factor assessment in the management of patients with suspected deep venous thrombosis," (with Motkyie, G. D.l et al.), International Angiology, (2000), 19, 47-51
    91.

    Statistical Inference and Other Topics

  91. "Inference based on regression estimator in double sampling," Biometrika (1978), 65, 419-427
  92. "Randomized response techniques for multiple sensitive attributes," Journal of the American Statistical Association, (1981), 76, 916-923
  93. "A note on the use of residuals for detecting an outlier in linear regression," Biometrika (1982), 69, 488-489
  94. "Exact repeated confidence intervals for Bernoulli parameters in a group sequential clinical trial," (with P. R. Coe), Controlled Clinical Trials, (1993), 14, 19-29
  95. "Small sample confidence intervals for the difference, ratio and odds ratio of two success probabilities," (with P. R. Coe), Communications in Statistics, Series B (Comp. and Simula.) (1993), 22, 925-938
  96. "Comparisons of confidence intervals for the difference of two independent binomial proportions," (with T. J. Santner, V. Pradhan, P. Senchaudhari and C. R. Mehta), Computational Statistics and Data Analysis (2007), 51, 5791-5799
  97. "The effects of media context experiences on advertising effectiveness," (with E. C. Malthouse and B. J. Calder), Journal of Advertising, (2007), 36, 7-18
  98. "Dry pea (Pisum satiuvum L) response to low rates of selected foliar- and soil-applied sulfonylurea and growth regulator herbicides," (with K. Al-Khatib), Weed Technology (1999), 13, 753-758
    99.

    Technical Reports and Other Publications

  99. "On minimax multistage screening type rules for selecting the largest normal mean," Ph.D. Dissertation (1975), Cornell University
  100. "A minimax two-stage permanent elimination type procedure for selecting the smallest normal variance," Tech. Report No. 260 (1975), Dept. of Operations Research, Cornell University
  101. "A randomized response technique for investigating several sensitive attributes," ASA Proceedings of Social Statistics (1977), 273-278
  102. "A simplified approach to the maximum likelihood estimation of the covariance matrix," Letter to the Editor, The American Statistician (1979), 33, 92-93
  103. Review of the book, "Design and Analysis of Experiments for Statistical Selection, Screening and Multiple Comparisons" by R. E. Bechhofer, T. J. Santner and D. M. Goldsman, Technometrics (1996), 38, 289-290
  104. "A multiple comparison procedure for three- and four- armed controlled clinical trials," (with L. A. Hothorn), Letter to the Editor, Statistics in Medicine (2001), 20, 317-318
  105. "Obituary: Charles W. Dunnett (1921-2007),"(with P. Macdonald), IMS Bulletin (2007), 36 (7), 6
  106. "Eulogy to Charles Dunnett (1921-2007)," Biometrical Journal, 50, 636-637

Sponsored Research

  1. ProSoft, Inc. \Improved Hochberg-Hommel Hybrid Procedures," 2/1/2012-8/31/2012
  2. National Security Agency, "A Statistical Modeling Approach to Some Problems in Data Mining for Multivariate Binary Data" 2/1/2007-1/31/2010
  3. National Heart, Lung and Blood Institute, "Decision Rules for Multiple Endpoints in Clinical Trials," 9/1/2006-10/31/2009
  4. DuPont, "Finding the maximum safe dose levels for heteroscedastic or ordinal data," July 2000-June 2003
  5. NSF (Div. of Undergraduate Education), "Quality Engineering Laboratory," (with B. Ankenman), 9/1/97-8/31/00
  6. DuPont, "Multiple test procedures for dose finding in safety assessments of crop protection compounds," 8/1/96-7/31/97
  7. NSF (Mathematical Sciences), "Mathematical Sciences Computing Research Environments," (with M. Tanner, S. Haberman and T. Severini), 8/1/95-7/31/97
  8. Northrop Corporation, "Statistical analysis of MANTECH data," 2-93 to 3-94
  9. British Science and Engineering Research Council: Visiting research fellowship, School of Mathematics, University of Bath, 6-88 to 9-88
  10. NSF, "Development of computing aids and techniques for process analysis," 2-86 to 1-89. (co-P.I. with R. S. H. Mah)
  11. Ford Foundation, "City of Chicago's demonstration/evaluation initiative under the maternal and child health block grant program," Faculty Participant, Center for Health Services and Policy Research, 10-83 to 7-87
  12. NSF, "Statistical multiple comparisons of several competing treatments," 4-77 to 8-79
  13. Office of Research and Sponsored Programs, Northwestern University, Faculty research grants in Summer 1975 and academic years 1976-77, 1980-82

Graduate Student Supervision

PhD Students Supervised or Under Supervision
  1. C. Iordache, "A Bayesian Approach to Gross Error Detection in Process Data," (co-advisor with R. S. H. Mah), Chem. Engg., March 1987.
  2. De Juran Richardson, "A Parametric Group Sequential Procedure for Comparing Survival Distributions of Two Treatments," Mathematics, May 1987.
  3. Paul Coe, "Exact Repeated Confidence Intervals for Binomial Parameters in Group Sequential Experiments," Statistics, October 1988.
  4. Dorothy Dunlop, "Developing Risk Factor and Disease Progression Marker Models for Longitudinal Cohort Data with Survival Endpoint," IE/MS, November 1990
  5. C. J. Kao, "Gross Error Detection in Serially Correlated Process Data for Static and Dynamic Processes," (co-advisor with R. S. H. Mah), Chem Engg., February 1991.
  6. G. V. S. Gopal, "A Bayesian Approach to Comparing Treatments with a Control," IE/MS, December 1991
  7. Edward Malthouse, "Nonlinear Partial Least Squares Using Neural Networks," (co-advisor with R. S. H. Mah), Statistics, August 1995.
  8. Brent Logan, "Contributions to Multiple Endpoints and Dose Finding," Statistics, June 2001.
  9. Ying Yang, "Identifying Location and Dispersion Effects for Ordinal Data from Industrial Experiments," IE/MS (co-advisor with B. Ankenman), December 2002
  10. Cindy Wang, "Gatekeeping Procedures for Multiple Endpoints," Statistics, June 2006.
  11. Jiaxiao Shi, "Improved Estimation of the Proportion of True Null Hypotheses with Applications to Adaptive Control of FDR and Drug Screening," Statistics, September 2006.
  12. Dingxi Qiu, "Cluster Analysis for Multivariate Normal and Bernoulli Data," (co-advisor with B. Ankenman), IE/MS, June 2007
  13. Kunyang Shi, "Power and Sample Size Determination for Dose Finding and Multiple Endpoints," Statistics, June 2010
  14. Lingyun Liu, "On Gatekeeping and Weighted Hochberg Procedures," Statistics, December 2009
  15. Yi Wu, "Group Sequential Procedures with Primary and Secondary Endpoints," Statistics, December 2012
  16. Dong Xi, "Topics in Gatekeeping and Group Sequential Procedures for Multiple Endpoints," Statistics, August 2013
  17. Jiangtao Gou, "Topics in Step-Up Multiple Test Procedures Based on p-Values," Statistics, June 2014

Seminars and Talks

  1. Multistage Elimination Type Procedures for Selecting the Largest Normal Mean
    • Ohio State University (Statistics Dept.), March 1974
    • Northwestern University (IE/MS Dept.), April 1974
    • Johns Hopkins University (Math. Sciences Dept.), April 1974
    • IMS Annual Meeting (Contributed Talk), Atlanta, August 1975
  2. Multiple Comparisons in Model I One-Way ANOVA with Unequal Variances
    • IMS Annual Meeting (Contributed Talk), New Haven, August 1976
    • Northwestern University (Statistics Seminar), November 1976
  3. Randomized Response and Weighing Design Techniques for Multiple Sensitive Attributes
    • ASA Annual Meeting (Contributed Talk), Chicago, August 1976
    • Northwestern University (Statistics Seminar), March 1977
  4. Inference Based on Regression Estimator in Double Sampling
    • Northwestern University (Statistics Seminar), October 1977
  5. Multiple Comparisons of Regression Models Based on Integrated Mean Square Prediction Error Criterion
    • University of Kentucky (Statistics Dept.), November 1977
  6. A Comparison of Procedures for Multiple Comparisons of Means with Unequal Variances
    • Western Regional Meeting of IMS and WNAR (Invited Talk), Los Angeles, June 1979
  7. Incomplete Block Designs for Comparing Treatments with a Control
    • Northwestern University (Statistics Seminar), February 1979
    • Northwestern University (ORSA Brown Bag Seminar), April 1979
    • University of Bombay (Statistics Dept.), April 1979
    • I. I. T., Bombay (Mathematics Dept.), India, April 1979
    • Renssalaer Polytechnic Institute (Statistics and OR Dept.), March 1984
  8. Designing Experiments for Selecting the Best of Several Normal Populations with Known Unequal Variances: Optimal Sample Size Allocation
    • Joint Annual Statistical Meetings (Invited Talk), Houston, August 1980
    • Cornell University (Statistics Seminar), November 1982
    • University of Rochester (Statistics Dept.), November 1982
    • Syracuse University (Mathematics Dept.), January 1983
    • McMaster University (Math. Sciences Dept.), March 1983
    • University of Bombay (Statistics Dept.), India, April 1984
    • I. I. T., Bombay (Mathematics Dept.), India, April 1984
    • University of South Carolina (Statistics Dept.), November 1984
    • University of Bath (School of Mathematics), U.K., July 1988
    • Northwestern University (Statistics Seminar), November 1988
  9. Multiple Comparisons: When and Why?
    • Chicago ASA Chapter (Biostatistics Interest Group), November 1980
    • N. E. Illinois ASA Chapter, October 1984
    • ENAR Spring Meeting (Invited Talk), Raleigh, March 1985
    • 42nd Annual Applied Statistics Conference (Three Hour Invited Tutorial), Atlantic City, December, 1986
  10. Teaching Careers in Statistics
    • ASA Chicago Chapter Careers Forum, November 1981
  11. Selecting the Better Bernoulli Treatment Using a Matched Samples Design
    • University of Illinois at Chicago (Mathematics, Statistics and Computer Science Dept.), May 1982
  12. Selecting a Normal Population with a Large Mean and a Small Variance
  13. Data Reconciliation and Gross Error Detection in Chemical Process Networks
  14. Some Problems in Probability Inequalities Arising in Multiple Comparisons of Means in Unbalanced Designs
  15. Conflicting Birthweight and Infant Mortality Trends in a High-Risk Urban Neighborhood
  16. Modern Methods for Quality Control and Improvement
  17. A Bayesian Approach to Gross Error Detection in Chemical Process Data
    • Northwestern University (Statistics Seminar), May 1987
  18. Multiplicity Problems in Biostatistics
  19. Designing Experiments for Step-Down Multiple Testing Procedures
  20. A Step-Up Multiple Test Procedure
  21. A Bayesian Approach to Comparing Treatments with a Control
  22. Some Recent Developments in Multiple Comparisons
  23. Stepwise Multiple Test Procedures and Their Applications
  24. Multiple Test Procedures for Dose Finding
  25. Multiple Test Procedures for Identifying the Maximum Safe Dose
  26. Multiple Test Procedures for Identifying the Minimum Effective and Maximum Safe Doses of a Drug
  27. Accurate Critical Constants for the One-Sided Approximate Likelihood Ratio Test of a Normal Mean Vector when the Covariance Matrix is Estimated
  28. Multiple Endpoints: Review and New Developments
  29. A Superiority-Equivalence Approach to One-Sided Tests on Multiple Endpoints
  30. Multiple Comparisons
  31. Multiple Comparison Procedures for Dose Response Studies
  32. Clustering for Multivariate Correlated Bernoulli Data
  33. Gatekeeping Procedures for Multiple Endpoints in Multiple Dose Finding Studies
    • Invited talk at the 5th Annual Connecticut ASA Chapter Mini-conference on Multiple Comparisons in the Pharmaceutical Industry, Meriden, CT, March 2006
    • Invited talk at the Midwest Biopharmaceutical Statistics Workshop, Muncie, IN, May 2006
    • Department of Mathematics and Statistics, Bowling Green State University, Bowling Green, OH, June 2006
    • Contributed talk at the International Biometrics Society Biennial Meeting, Montreal, July 2006
  34. A Mixture Model Approach to Estimating the Number of True Null Hypotheses and Adaptive Control of FDR
  35. Tree-Structured Gatekeeping Procedures for Multiple Endpoints
  36. On Weighted Hochberg Procedures
  37. General Stepwise Gatekeeping Procedures
  38. Testing a Primary and a Secondary Endpoint in a Group Sequential Design
    39.
    • Contributed talk, VIth International Multiple Comparison Procedures Conference, Tokyo, Japan, March 2009
    • Invited talk, Department of Biostatistics, Columbia University, New York, NY, September 2009
    • Invited talk, ASA Chapter, Milwaukee, WI, October 2009
    • Invited talk, Annual JSM, Vancouver, August 2010
  39. Gatekeeping Procedures
    40.
    •  Invited talk, Multiple Comparisons in Clinical Trials Conference, ExL Pharma, Rockville, MD, January 2010
    •  Invited talk, NIC/ASA Chapter Spring Workshop, Northbrook, IL, March 2010
    •  Invited talk, Department of Statistics, Northern Illinois University, DeKalb, IL, November 2010
  40. Mixture Gatekeeping Procedures with Clinical Trial Applications
    41.
    •  Invited talk, ENAR Spring Meeting, Miami, FL, March 2011
    •  Invited talk, International Indian Statistical Association Conference on Probability and Statistics, Raleigh, NC, April 2011
    • Invited talk, International Chinese Statistical Association Conference, New York, NY, June 2011
  41. Testing a Primary and a Secondary Endpoint Using a Two-Stage Group Sequential Procedure: An Adaptive Extension for Unknown Correlation
    42.
    •  Contributed talk, VIIth International Multiple Comparison Conference, Rockville, MD, August 2011
  42. Multiple Comparisons for Multiple Endpoints and Multiple Doses
    43.
    •  Invited talk, American Course on Drug Development and Regulatory Sciences (ACDRS), Frontiers in Drug Development and Regulatory Sciences, University of California at San Francisco, CA, October 2011
    •  Invited talk, Workshop on the Design and Analysis of Clinical Trials, Institute of Mathematical Sciences, National University of Singapore, October 2011
    •  Invited talk, Department of Mathematics, Statistics and Computer Science, University of Illinois, Chicago, March 2012
    •  Invited talk, 2012 ASA Connecticut Chapter Mini-Conference, New Haven, CT, March 2012
  43. Multiplicity Problems for Composite Endpoints
    44.
    • Invited talk, 5th Annual FDA/MTLI Medical Device and IVD Statistical Issues Workshop, Washington, DC, May 2012
  44. A Class of Improved Hybrid Hochberg-Hommel (HH) Procedures
    45.
    •  Contributed talk, Adaptive Designs and Multiple Testing Procedures Workshop, Heidelberg, Germany, July 2012
    •  Invited talk, Department of Mathematics and Statistics, University of South Alabama, Mobile, AL, March 2014
  45. A General Multistage Procedure for k-out-of-n Gatekeeping
    46.
    •  Invited talk, International Indian Statistical Association (IISA) Meeting, Chennai, India, January 2013
    •  Invited talk, Department of Statistics, University of Poona, Pune, India, January 2013
  46. Allocating Recycled Signi cance Levels in Group Sequential Procedures for Multiple Endpoints
    47.
    •  Invited talk, VIIIth International Multiple Comparison Procedures Conference, Universityof Southampton, UK, July 2013
    •  Invited talk, NIC/ASA Fall Workshop, Glenview, IL, October 2013
  47. False Findings in Scienti c Research
    48.
    •  Invited Public Lecture, University of South Alabama, Mobile, AL, March 2014
  48. Hochberg Multiple Test Procedure Under Negative Dependence
    49.
    •  Invited talk, International Indian Statistical Association (IISA) Meeting, Riverside, CA, July 2014
    •  Keynote talk, IMPACT Symposium organized by University of North Carolina at Chapel Hill, Cary, NC, November 2014

Short Courses

  1. Multiple Comparisons, One-Day Course
    • Spring Biometrics Society (ENAR) Meeting, Cleveland, OH, April 1994
    • Ciba-Geigy Corporation, Summit, N. J., November 1983, December 1993
    • Schering-Plough Corporation, Kenilworth, N. J., November 1987
  2. Multiple Comparisons (with Y. Hochberg), Two-Day Course
    • Groupe Biopharmacie-ASU, Paris, France, June 1993
  3. Multiplicity Problems in Pharmaceutical Studies (with B. W. Turnbull), Two-Day Course
    • FDA, Rockville, MD, December 1988
    • Abbott Laboratories (together with G. D. Searle Co.), North Chicago, IL, June 1989
    • Sterling Drug Inc., Rensselaer, NY, June 1989
    • Merrell Dow Research Institute, Cincinnati, OH, June 1990
    • Bristol-Myers-Squibb, Hartford, CT, September 1990
  4. Design of Industrial Experiments
    • Northrop Corporation (Defense Systems Division), Rolling Meadows, IL, December 1990 - February 1991, October 1992 - December 1992
    • McCormick School of Engg. & Applied Science Continuing Education Program (with J. Mellon), October 1994
  5. Design of Experiments Workshop for High School A P Stats Teachers
    • Council of AP Stats Teachers and N. E. Illinois ASA Chapter, October 2000
  6. Multiple Endpoints and Gatekeeping Procedures (with A. Dmitrienko)
    • FDA, Silver Spring, MD, October 2008
    • MCP2009 Conference, Tokyo, Japan, March 2009
  7. Multiple Comparisons for Multiple Endpoints and Multiple Doses
    • Design and Analysis of Clinical Trials Workshop, Institute of Mathematical Sciences, National University of Singapore, October 2011
  8. Multiple Test Procedures for Gatekeeping
    •  Amgen, Thousand Oaks, CA, August 2011
    •  VIIth International Multiple Comparison Procedures Conference, Rockville, MD, August 2011 (with A. Dmitrienko)
    •  Indian Association for Statistics in Clinical Trials (IASCT), Pune, India, January 2013
  9. Multiple Testing Procedures with Gatekeeping and Graphical Applications (with Dong Xi)
    •  FDA-Industry Statistics Workshop, Washington, DC, September 2014
    •  Abbvie, North Chicago, IL, April 2015

Consulting

  1. Allergen, Irvine, CA (2013-Present)
  2. Amgen, Thousand Oaks, CA (2011-Present), Member of Data Monitoring Committee for clinical trials
  3. Cytel International, Boston, MA (2007-Present)
  4. Boehringer Ingelheim, Ridgefield, CT (2006-Present)
  5. Novartis Pharma, East Hanover, NJ (2005)
  6. Johnson & Johnson Pharmaceutical Research & Development, Raritan, N. J. (1998-2004)
  7. Harza Engineering, Chicago, IL (2001-2002)
  8. Medical Research Laboratories, Buffalo Grove, IL (2000-2002)
  9. Technology Management Group, Des Plaines, IL (1998-2000)
  10. Haemoscope Corporation, Skokie, IL (1997-1998)
  11. NCM Publishers Inc., New York, NY (1995)
  12. RCT, Wheeling, IL (1994-1995)
  13. Venatech Inc., Evanston, IL (1993-1997)
  14. American College of Pathologists, Northfield, IL (1992)
  15. Northrop Corporation (Defense Systems Division), Rolling Meadows, IL (1990-1994)
  16. National Cement and Ceramics Laboratory, Evanston, IL (1990-1991)
  17. Glenbrook Hospital Human IVF Laboratory, Glenview, IL (1989-1990)
  18. Vascular Care Technology Inc., Glenview, IL (1989-1993)
  19. Northwestern University Medical School (1988-1990)
  20. United Refining and Smelting, Franklin Park, IL (1988)
  21. Kendall Research Center, Barrington, IL (1981-1986)
  22. Engineered Coated Products, Northbrook, IL (1986)
  23. Mark Control Inc., Evanston, IL (1981)
  24. Bell and Howell Educational Group Inc., Evanston, IL (1981)
  25. Educational Testing Service, Evanston, IL (1980)
  26. Northwestern Illinois Planning Commission, Chicago, IL (1980)
  27. Shure Brothers Inc., Evanston, IL (1979)

Professional Activities

last update 3/5/2015